Making CAS BioFinder

A 0 → 1, design and research driven product with over 1,500 users which delivers drug/target/disease relationships with 82% time-to-task completion for biologists and medicinal chemists, netting $3.67M additional revenue for the 2025 fiscal year.

Create a platform of solutions for medicinal chemists and biologists to search curated and connected data to make informed decisions regarding the drug-discovery process.

CAS BioFinder started as a concept, codenamed "Darwin" in 2016, for an expansion into the biologics space for CAS content curation. A prototype was developed during that time and informed a lot of preliminary research which was inherited for this project. CAS was also actively benchmarking existing software solutions to retrofit a framework and functionality to break into this space.

The double diamond framework used across all UX program discovery and definition work

While vetting a software called Chemotargets by Clarity, I began creating a framework for generative research. This software was developed by an academic firm without any user research or design processes. The UX program I manage leverages the double diamond paradigm for discovery, definition, ideation, and implementation across all products.

Using the existing application, the Darwin concept, and similar product benchmarks, I designed low-fidelity prototypes to convey organizational concepts and information for research candidates. The challenge was finding clean data representative of CAS content curation efforts. Scientists require factually accurate information to feel comfortable remarking on the efficacy of a prototype in research.

After commissioning and collaborating on research with an external agency, I participated in interview sessions using rapid iterative testing and evaluation (RITE) usability assessments to quickly address gaps in the design and workflow. Three key themes emerged:

• Customers wanted a one-stop shop for all drug and ligand details, with the ability to compare binding affinity against known protein targets.
• Referential information from journals and patents was critical to validate hunches and search findings for ligands and their protein pairs.
• The ability to upload proprietary molecules and algorithmically determine predicted binding affinity was highly desired, presenting a unique challenge around intellectual property security.

Initial prototype architecture and persona workflow map

I worked directly with the product manager to prioritize epics of work which would create the core information architecture as defined and validated by user research. In total, 215 epics were created for the commercial launch. This level of planning provided visibility and guidance for engineering efforts and sizing of work.

Working closely with the product manager, I created high-fidelity mockups and production-ready specifications in Figma, coinciding with our team's transition from Adobe XD. I actively developed a product-specific design library and components to expedite specification creation. Assets were delivered using Dev Mode in Figma, which the engineering teams were delighted to learn.

Transitioning to Figma enabled more spontaneous transparency with product and engineering teams. I closely collaborated with front-end engineers to ensure tighter designs and experience workflows, meticulously documented in JIRA. Before each new build was pushed to the beta program, I partnered with QA to ensure designs were implemented to specification.

Figma production specs and JIRA sprint tracking for the 215-epic build

After 11 months of development, the application launched commercially in May 2024. Throughout launch, multiple sessions were conducted soliciting feedback to discover additional desired functionality based on beta usage of the MVP.

We discovered that 72.6% of users preferred searching by drawn or known structures rather than text-based queries (27.4%). Of existing and potential customers surveyed, 82% said this solution was highly desirable and were excited to purchase at release.

Alpha release screens: ligand results, drug detail, and predictive analytics

After launch, we monitored usage daily and kept close tabs on sales motions. While feedback was positive, I began crafting second-version drafts to adjust the UX to be more aligned with what medicinal chemists and biochemists would expect, with greater integration of protein and disease detail pages.

Production adoption was initially slow, as CAS's primary sales mechanism targeted chemists. Leadership determined that an open trial period would drive growth, leveraging existing customers as advocates to their biological peers and encouraging them to try BioFinder in their daily research.

It was during this period that the UX team vetted Appcues, an in-product messaging and onboarding tool, to create first-time onboarding flows and explain new features. Monitoring user activity and listening to feedback in research sessions I moderated, I compiled a list of features and enhancements to feed the roadmap and satisfy a third user persona: the biologist.

First-time onboarding flow designed in Appcues, guiding users through BioFinder's core search types

The first release of BioFinder was intended to hook familiar customers in the pharmaceutical chemistry space. The second major release added:

• Two additional search types, proteins and diseases, tying all search types together to allow users to navigate the application from anywhere in their workflow.
• An activity analysis heat map allowing medicinal chemists to compare binding affinity of ligands against a target of interest.
• A revamped ligand and drug detail page for expanded content types.
• Refined predictive analytics to expand modeling capabilities, showing chemical structures next to protein and gene data for enhanced visualization.
• Revamped sequence search capabilities for biologist personas to search proteins by sequence algorithms, linking directly to protein and gene detail pages.
• Drug Intelligence to summarize FDA drug authorizations, dosages, and dates of approval.

CAS BioFinder v2: homepage, ligand results, ligand detail, and disease search

Over the summer of 2025, sales effectively closed 12 major deals, including two academic consortia, opening use cases for university research. The result was $3.67M in additional revenue across 14 countries.

Data as of December 2025

BioFinder is one of the most technically demanding products I have worked on. The users are world-class scientists, the data is extraordinarily complex, and the stakes, from drug discovery to disease research, are as high as they get.

What made it work was an unflinching commitment to user research at every stage. The 215 epics didn't come from guesswork. They came from listening carefully to medicinal chemists, biologists, and computational scientists, and translating what they needed into an experience that respected both their expertise and their time.